Objective: The free radical is a well-known and recent theory of aging. In this theory the oxygen radicals injury and lipid peroxidation are msjor causes of the disease and aging process. Bojungikgi-tang and Yukmijiwhg-k7ng, the prescriptions of oriental medicine, consist of some medicinal herbs. These are generally used for the treatment of aging-related diseases in old man. The effects of Bojungikgktung and Yukmuiwhg-tang were supposed to posses antioxidative activity Method: Bojungikgi-tmg and Yukmjiiwhang-tang in aging, FAP, CD and the activities of antioxidant enzymes in liver were measured on SAM P-1 and R-1 in 4, 12, 24 and 40 weeks of age.
Result: BojungikghWag and Yukmuiwhrurg-tang did not change FAP intensity but reduced CD intensity in 40 weeks of age, and increased significantly the activities of glutathione pwoxidase, glutathione reductase, glutathione S-transferase, catalase and superoxide dismutase of SAM P-1 in old weeks of age.
Conclustions: Bojungikgi-i-tang and Yukmuiwha,ng-tang play a significant role in the antioxidative reaction and protecting of lipid peroxidation associated with aging.
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